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482 posts categorized "Health business"

May 20, 2016

Mayo Clinic Ventures looks to Israel for collaborations

Looking to help boost a variety of medical start-up businesses, Mayo Clinic Ventures is targeting collaborations and investments in Israel with a new program.

The goal of the Mayo Clinic Israeli Startup Initiative is to work with companies either through sponsored research grants or co-development.  

Flags"Co-development can include licensing of Mayo Clinic know-how or an investment," explained Timmeko Love, of Mayo Clinic Ventures. "It's about matching the right opportunities with Mayo Clinic know-how for collaboration. It's all about finding the right strategic fit."

Candidates for the Israeli Startup Initiative can include very early stage companies to ones that are much further along in development. They can work in any area of health care. 

"We're not limiting our options," Love said.

The project announced this week actually is a new phase of an existing Mayo Clinic initiative.

It has been active in Israel for about a year, partnering with the philanthropic Merage Institute. The California-based Merage Institute awards up to $150,000 in annual research grants for Israeli companies working with Mayo Clinic. The most recent recipient was EyeYon Medical, which makes a noninvasive medical device to treat corneal edema.

Mayo Clinic Ventures recently took on the Israel initiative and that has put co-development on the table. That new approach is being launched next week in Tel Aviv at IATI-Biomed, Israel’s largest life sciences and technology conference. Mayo teams will meet start-ups to study their technology, and then consider making investments or collaborations.

This is first time Mayo Clinic Ventures has focused on one whole country for business opportunities, despite its long history of international projects. Many might not be aware of it, but Israel is a logical candidate for a such a relationship.

"It's a natural next step for us," Love said.

Israel is considered to be the worldwide leader in innovation in medical devices, biopharma, software and other types of health-care businesses. The U.S imported $600 million of Israeli medical devices in 2011. In 2015, Israel housed 725 medical-devices businesses with an overall total of 1,380 life-sciences companies.

While California's Silicon Valley is known as the hottest spot in the world for business start-ups, Israel is recognized as a close second. A 2009 book, "Start-up Nation," documents how Israel, with a population of 7.1 million, generates more tech businesses than many much larger countries.

"It's kind of a national sport in Israel," said Guy David, a professor of health-care management at University of Pennsylvania’s Wharton School. He was born and raised in Israel and tracks its medical businesses closely.

David said Israel's required military service coupled with an environment that encourages questioning and taking risks is a big factor.

"Israel is hugely innovative. The innovative spirit starts at a very young age," he said.

While launching technology companies is a big focus in the country, the entrepreneurs all know the market for their products or services is elsewhere.

"There is no market in Israel. Israel is tiny," said David. "If they invent something, they know it has to be a global product."

Does that mean businesses partnering with Mayo Clinic could open offices or build facilities in Rochester?

"That certainly could be a possibility. We do look at an economic development when considering companies," said Love. "But it has to make sense for that company. There would need to be a business reason for it."

 

May 17, 2016

Mayo Clinic to take over Biobusiness Center floor as Celyad pulls out

Mayo Clinic is returning to the fifth floor of Rochester's Minnesota BioBusiness Center, after a Belgium-based biotech firm left it empty for more than a year. 

In March 2015, the Rochester City Council approved a five-year lease for Mayo Clinic-linked Celyad to take over the fifth floor to create a prototype manufacturing facility that would add 33 jobs to Rochester.

CelyadCelyad's lease meant displacing all the Mayo Clinic workers based on that floor. Mayo Clinic moved its employees out at the start of 2015.

However, the project didn't go as planned. Celyad, formerly known as Cardio3, was unhappy when development costs came in much higher than the estimate provided by the city. 

051509biobusinesscenteratnight"The budgets we got far exceeded initial assumptions on which the project was decided," said Celyad CEO Dr. Christian Homsy in an email from Belgium in November. "Including the city support, the fit-out cost now exceeds the cost to do the same work in other locations where there is no city or state support."

Celyad halted the project before any construction work was done, so the 14,963 square feet of space remained just as Mayo Clinic left it. However, the biotech company did uphold its end of the lease and has been paying rent of $22,444.50 per month, or $269,334 per year. City officials say the company has made all of the required payments.

Since the end of 2015, the city has been looking for a new tenant to take over the fifth floor. Now, the city has approved a new lease with an old tenant.

The new deal adds the fifth floor to Mayo Clinic's lease, which already includes four floors of the seven-year-old building. 

"The lease amendment would provide for a rental rate of $17 per square foot for the 'premises,' which consists of the entire fifth floor. That rate would be in effect for a term consistent with the present term for the other four floors through April 1, 2029," according to the agreement approved by the Rochester City Council on Monday. 

Mayo-clinic-logoThat's $1 less per square foot than the $18 per square foot Celyad has been paying.

Before approving the new Mayo Clinic lease, the city council OKed the termination of the Celyad agreement. It called for Celyad to continue paying its regular rent through Sept. 30, plus "a lease termination fee" of $111,549.18. 

That fee will cover costs for the space from October to Jan. 1. Mayo Clinic will be building out the space starting in October and it will began paying rent in January. Mayo Clinic plans on using the floor to help teams that need more room.

"Planned occupancy will include relocating certain research support teams in need of additional office type space," stated Kelley Luckstein, of Mayo Clinic Media Relation, in an email.

Celyad's relationship with Rochester began in 2007, when it licensed stem-cell research by Mayo Clinic's Dr. Andre Terzic and Dr. Atta Behfar. It was called Cardio3 Biosciences back then. They have collaborated for years on the cardiopoiesis technology the company uses to repair patients' hearts by re-programming their own stem cells to regenerate cardiac tissue. Mayo Clinic owned 2.69 percent of Celyad as of March 3, 2015.

Beyond the fifth floor prototype manufacturing facility, the Celyad deal was designed to clear the way for the biobusiness to possibly build a 100,000-square-foot manufacturing facility with 350 employees in Rochester. That's what the company anticipates it will need if the Federal Drug Administration gives it a green light to take its stem-cell treatment to market.

Celyad's Homsy says Rochester now is out of the running for that.

"Celyad has assessed that a manufacturing plant in Rochester at this point of time cannot be justified.  We have opened an office in Boston from where our U.S. management is based, but we have delayed the decision on a manufacturing plant in the U.S. as we are able to manufacture all clinical lots out of our Belgian facility. As we approach commercial launch in the U.S., this situation may be revisited," he responded from Belgium by email.

Though the relationship between Rochester and Celyad has diminished dramatically in recent months, Homsy said it is not completely over.

"We continue to collaborate with Mayo Clinic, as well as with Andre Terzic, in the context of the evaluation of our CHART-1 data that should be disclosed by end of June 2016. If the data is positive, further development in the U.S. in the form of CHART-2, and, potentially, commercialization would follow," he stated.

March 04, 2016

Mayo Clinic to issue $300 million in bond

Mayo Clinic is issuing $300 million of taxable bonds this month raise funds for "general corporate purposes."

A 200-page preliminary offering memorandum was filed March 3. The bonds are being offered in denominations of $1,000 "and integral multiples thereof…." Starting on Nov. 15, 2016, interest on the bonds is payable every May 15 and Nov. 15.

Mayobonds"Mayo will use the proceeds of these bonds for general corporate purposes," according to Mayo Clinic's Susan Barber Lindquist.

Mayo Clinic, which has AA ratings from Moody's and Standard & Poor's, regularly issues taxable bonds and tax-exempt bonds to fund projects. More bonds are scheduled to be issued this spring.

"In early May, Mayo also plans to issue $250 million of tax-exempt variable rate bonds, the proceeds of which will be used to refund $200 million of fixed rate bonds issued in 2006 through municipal authorities in Jacksonville, Florida; and Rochester; and for new projects in Rochester," wrote Barber Lindquist in an email statement.

She added that, "Mayo also plans to retire the $50 million of tax-exempt fixed rate bonds  issued in 2006 through Maricopa County, Ariz. The 2006 bonds are subject to optional redemption on May 15, 2016."

Through refunding and retiring bonds, the end result should be that the "… Total net new debt of Mayo Clinic will not exceed $300 million," she wrote.

The March 3 bond memorandum included an independent audit of Mayo Clinic. That audit spotlighted many aspects of Mayo Clinic's operations.

• $281 million in revenue from "Retail pharmacy sales" in 2015. That is up $30 million from $251 million in 2014.

• $31 million in revenue from "Graduate Medical and Other Education." That is down $10 million from $41 million in 2014.

• $38 million from "Cafeteria Revenue" in both 2015 and 2014. It made $31.8 in 2011.

• $65 million in revenue from "Royalties." That an increase from $52 million in 2014.

• $41 million in revenue from "Retail stores" in 2015. That's sharp increase from the $20 million in retail store revenue reported in 2014.

• $14 million in revenue from "Oil- and gas-producing activities. That's a decrease from $24 million in 2014.

• $73 million of "Charity Care" was provided to patients in 2015. That is down from $76 million in 2014.

• Mayo Clinic reported $6 million in income taxes, "including interest and penalties for uncertain tax positions" for 2015. The filing added, "It is not anticipated that a significant change in the reserve will occur over the next 12 months."

January 20, 2016

New owners, old name at Northgate Health Club

A longtime Rochester health club is getting an upgrade under new owners as it returns to its old name.

When Dan and Ronaele Hoffman took over Northgate Fitness and Wellness Center in November, one of the first things they did was ask employees and clients about the name.

"Employees preferred the old name of Northgate Health Club. That's what people call it in the community, so we decided to change it back to Northgate Health Club," said Dan Hoffman.

12472391_10153879088087292_5822154243486821442_nBesides returning the 47-year-old center to its original name, the Hoffmans plan to update all areas of the club at 1112 Seventh St. NW in the Northgate Plaza.

"We've already made improvements in the free weights room and there's a lot more to come," he said.

Northgate Health Club has a team of 30 employees on staff.

The Hoffmans bought the club from Prow Co., which owns the shopping center. The idea of buying it came up as they were outfitting a health club in their other property, the Grand Meadow Business Center.

"We starting looking at it. Pretty soon we decided the culture was right, so we bought it," explained Dan Hoffman.

December 16, 2015

New Stewartville firm to collaborate with Mayo Clinic

A new medical device company launched by well-known local experts is joining forces with the top health care name in the region - Mayo Clinic.

Minnesota Medical Technologies, recently started by Jim and Philip Conway, announced this week that it will collaborate with Mayo Clinic in the development of new fecal incontinence products. As part of the deal, Mayo Clinic will have some ownership of Minnesota Medical Technologies.

5627967a5e7bd.imageThe Conways have experience working with Mayo Clinic at their former company, Rochester Medical, which made catheters and urinary incontinence products.

"We are pretty expert in fabricating and designing devices, but we can't pretend to experts in the medical field. That's why working with Mayo Clinic makes sense," said Jim Conway. "It's very likely when we get our first patents, a Mayo Clinic name will also be on it."

The Conway brothers, along with partners Lonnie Boe and Sarah Grinde, are building a 6,500-square-foot pilot manufacturing facility in Stewartville's Schumann Business Park. Jim Conway says the goal is to start using the building sometime in April with early prototype production starting soon after.

"We're shooting to get FDA approval by the end of 2016," he said.

Minnesota Medical is already working on the early groundwork to develop a dual U.S.-European market for these new products. Like when they entered the catheter field in 1989, the Conways see a lot of opportunity to develop better products in area where there is a lot of need.

Fecal incontinence affects an estimated 1 percent to 2 percent of the general population and 40 percent to 50 percent people living in long term care facilities. U.S. sales of fecal incontinence products is predicted to hit $1.9 billion by 2018. Minnesota Medical is targeting 10 percent of U.S. and international sales, a goal they hit with Rochester Medical and urinary incontinence.

Rochester Medical grew into a major international manufacturer with hundreds of local employees and more than $60 million in annual sales. In 2013, the Conways sold it to rival C.R. Baird for $262 million. They signed a five-year, non-compete agreement not to make urinary incontinence products.

November 04, 2015

What's the skinny on new subway spa?

A well-known Rochester downtown subway business now has more skin in the game with the opening of Total Image Esthetic Center.

Hillary Seltun opened the new medical spa in the Kahler Hotel subway, across the hallway from Hanny's, on Oct. 30. She owns the spa with her husband, Joseph Seltun. They also own the nearby Total Image Hair Salon, which has operated in the subway for more that 50 years.

TemplogoThe Seltuns' skin services out grew the treatment room at Total Image Salon and the Kahler offered them more space as another spa closed and sold off its equipment, said Hillary Seltun.

"It all just came together at the right time," she said. "It just made sense to expand."

The new center offers a full array of skin services including facials, Botox, massage, chemical peels, laser treatment, makeovers, spray tan and a eyelash/eyebrow bar. They also offer bridal packages in conjunction with the Kahler Hotel.

While some other spas in Rochester offer similar services, the Seltuns are comfortable with opening a new competitor.

"I feel like there is more than enough demand. And I think we're a little bit different," Hillary said. "We understand a woman's need to feel good as well as look good."

Being in the subway also may give them an edge.

"I feel like the subway system is kind of like its own a city within a city," she said. 

October 28, 2015

New Roch. substation planned for Epic, Mayo Clinic growth

Mayo Clinic's partnership with Epic Systems, the largest electronic medical records firm in the United States, is driving the construction of a new $6.1 million Rochester Public Utilities substation.

Epic_Systems_112109_SignVerona, Wis.-based Epic Systems has been negotiating with RPU since June about the project. Epic says it needs more power capacity in the area to support future growth of the Mayo Clinic Data Center at 4710 West Circle Drive. The new Douglas Trail substation is slated to be built by the data center on land currently owned by Mayo Clinic.

The RPU board approved a "memorandum of understanding" about the project with Epic at its Tuesday night meeting. An escrow account already has been set up to fund project.

The memorandum states, "Due to the planned transfer of selected Mayo Data Center assets to Epic, Epic requests incremental electrical capability and capacity, needed to accommodate projected business growth in forward years…"
Epic has agreed to pay for the majority of the $6.1 million project, with RPU contributing $1.016 million for additional features that Epic doesn't need. The agreement also allows for Epic to apply  Mayo4710technologyparkfor up to $2.03 million in rebates over 10 years. The goal is to have the new substation up and running at least by April 1, 2017.


Rochester attorney Mark Utz spoke to the board as a representative of Epic. He said the deal  "Provides capacity not just for Epic, but a tremendous opportunity for the city of Rochester … to have a third substation in an incredible quadrant for Rochester. This is a win/win for the community, for RPU and for Epic."

Bruce Richards, Epic's director of facilities and engineering, assured the board his company is serious about coming to Rochester.

"This is a long-term situation for us. We're bringing in quite a few people to town," he said. "We'll start out with 80 to 90 people to the data center to work with Mayo Clinic."

Richards told the RPU board the additional capacity is needed for the potential that the current data center could grow to three times its current size.

Mayo Clinic built the $33.7 million, 60,000-square-foot computer support center in 2012. The data center was built to support all three of Mayo Clinic's campuses — Rochester, Jacksonville, Fla., and Scottsdale, Ariz.

"Epic is expected to take title of the property nominally in December 2015, with site grading to begin in spring 2016, according to the RPU/Epic agreement. The agreement also states that, "It is contemplated that the City of Rochester, for the benefit of RPU, will acquire from Epic the title of the real estate where the substation and related infrastructure will be located.

Richards did not elaborate on what Epic plans to do at Mayo Data Center, though remote hosting medical records is a possibility. In recent years, Epic built a massive data center in Verona, Wis. to offer remote medical record hosting for its clients.

6a00d83451cc8269e201b7c791bc82970b-800wiEpic and Mayo Clinic began working together early this year, when Mayo chose Epic to handle Mayo Clinic's electronic medical records. The relationship is developing into a close collaboration. Mayo's Chief Administration Officer Jeff Bolton has said that Epic has shown "a strong interest" in being part of the planned Discovery Square development in downtown Rochester. Discovery Square is part of Mayo Clinic's Destination Medical Center initiative.

Epic has about 8,000 employees and had $1.8 billion in revenues in 2014. Epic's software already is used by about 350 health-care organizations that care for 54 percent of U.S. patients.

Mayo Clinic is not Epic's only major partner in northwest Rochester. In May, IBM Watson Health, the health care unit of IBM, announced it has begun working with Epic as well as Mayo Clinic to add the Watson' super computer's cognitive capabilities to electronic health records. It's not clear if IBM is involved in the West Circle Drive data center project.

October 19, 2015

Does Mayo Clinic + ex-US Postal center = dirty laundry?

Is dirty laundry in the mix as Mayo Clinic figures out how to use the ex-U.S. Postal Service facility it bought in July?

The buzz in the local spin cycle is that Mayo Clinic might convert the 72,662-square-foot facility at 3939 Valleyhigh Drive into a commercial laundry. Right now, Mayo Clinic contracts with the Kahler Hospitality Group's Textile Care Services to clean the mountains of dirty linen it produces every day.

FireShot Capture - 3676 Valleyhigh Dr NW - Google Maps_ - https___www.google.com_maps_@44.0579The original Kahler Hotel owners and Mayo Clinic started TCS in 1918 as a joint operation. Mayo Clinic pulled out of ownership in 1996 and has contracted with Textile Care ever since.

Officials at Textile Care had no comment on the rumor. Mayo Clinic didn't really answer the question, but it did offer up a cryptic statement.

6a00d83451cc8269e2014e889d360b970d-800wi"No decisions have been made regarding use of the former U.S. Postal building. Mayo Clinic has an agreement with Textile Care Services that extends into 2018 and potentially longer," wrote Mayo's Kelley Luckstein in an email.

So … does that mean maybe? I guess it'll all eventually come out in the wash.

October 01, 2015

A Mayo Clinic linked firm working with DMC planner to develop new Madison biosciences hub

A firm with deep ties to Mayo Clinic is making a move to anchor a downtown Madison, Wis., biosciences hub with help from the development manager of Rochester's Destination Medical Center initiative.

Exact Sciences Corp. licensed technology from Mayo Clinic in 2009 and 2012 for Cologuard, a stool-based DNA test for colorectal cancer. The test is based on research by Mayo Clinic's Dr. David A. Ahlquist and his laboratory.

LogoOriginally based in Boston, city officials at one point hoped Exact would move to Rochester. However, Madison gave the company $1 million to move its headquarters there in 2009.

Since then, the company has flourished, and now it's planning to build a new $200 million, 250,000-square-foot headquarters in downtown Madison with $46.7 million in financial aid from the city.The Madison City Council recently OKed the deal, which requires that Exact will have 400 employees in the building by 2019.

The developer of the project is JDS Development LLC, which is a joint venture between Hammes Co. and Majestic Realty. Hammes is the Wisconsin consultant that is in charge of DMC. It also is working directly with Mayo Clinic on the Discovery Square portion of the DMC project. Hammes also has been hired by the Rochester Convention and Visitors Bureau to do a feasibility study for the proposed hockey arena to house a possible US Hockey League team here.

Hammesco_blue_logoHammes' Exact development will include a 250 room hotel, a food court, health and wellness facility, conference and media centers and lots of room for retail and restaurants.

Exact CEO Kevin Conroy told the Madison City Council that, "We hope that by having a life science company headquarters in downtown Madison, it will spur economic development throughout the region and have a positive impact on downtown."

September 01, 2015

Celyad, Medisun collaborating on new China deal

Two international firms with deep Mayo Clinic and Rochester ties are joining forces for a new $22.4 million collaboration. 

Belgium-based Celyad, formerly called Cardio3, announced Monday it's entering into a new venture and distribution deal with its partner, Medisun International Limited, for its C-Cure cardiac treatment. C-Cure is based on stem-cell technology called cardiopoiesis licensed from Mayo Clinic.

CelyadBoth Celyad and the Hong Kong-based Medisun continue to collaborate with Mayo Clinic and both are in the process of creating facilities in Rochester.

This new 15-year agreement between Celyad and Medisun guarantees Celyad will "conduct all clinical development and undertake any regulatory steps necessary for market approval in China, Hong-Kong, Taiwan and Macau (collectively 'Greater China')," according to a news release about the venture.

Medisun will fund that push with a minimum of 20 million Euros, or $22.4 million. In addition to the funding cash, Celyad will collect royalties and profit sharing. The royalty rates, based on the total revenues from C-Cure, are expected to range from 10 percent to 30 percent. Profit-sharing amounts will be based on total revenues after royalties are taken out. The profit sharing is expected to range from 20 to 25 percent.

"We are pleased to have this new license agreement in place with our local partner Medisun, which give us full control over clinical developments in these territories, fully funded by our local partner. Pending receipt of necessary approvals, we look forward to giving access to this technology to patients in Greater China," stated Celyad CEO Christian Homsy in the release.

6a00d83451cc8269e201b8d0c98293970c-120wiCelyad is paying rent on the entire fifth floor, or 14,963 square feet, in the city of Rochester's Minnesota Biobusiness Center. The city signed a lease with Celyad earlier this year for it to develop a prototype manufacturing facility in the downtown building. Construction has been underway for months, but is not yet completed. The five-year lease calls for Celyad to pay a rent of $18 per square foot, or $22,444.50 per month. The city agreed in the lease to pay for $600,000 in equipment and improvements to the space.

Local officials hope to convince Celyad to build a 100,000-square-foot manufacturing facility with 350 employees in Rochester, according to officials at Rochester Area Economic Development Inc.  Celyad also has plans to build a U.S. headquarters in Boston.

The company recently reported a $17.04 million loss for the first half of 2015. It lost $18.1 million for the whole year in 2014, up from $15.9 million in losses in 2013. Dr. Homsy told Reuters last week the company has enough cash to make it through the end of 2017.

The company did an initial public stock offering in 2014, which yielded about $500,000 worth of shares for Mayo Clinic.

Medisun also is collaborating with Mayo Clinic on a project to bring more patients from China to Rochester for treatment. While Medisun began building a $1 million office in the H3 Plaza building in downtown Rochester earlier this year, it recently put an end to that project.

Mayo Clinic, however, has confirmed it still is working with Medisun. Mayo Clinic spokeswoman Duska Anastasijevic said she didn't believe "the scope and nature of the relationship has been impacted or altered, just the planned location of their offices has changed." 

She added that Mayo staff working with Medisun said the company will be using one of its Rochester homes as "a guest house" and headquarters for the project. Medisun CEO Danny Wong personally owns two houses in Rochester. He bought a house at 2515 Crest Lane SW for $1.4 million as well as one at 615 10th Ave. SW for $1.31 million. It is not known which property will serve as the guest house.